Mandell, Douglas, And Bennett's Principles And Practice Of Infectious Diseases, 7 Edition.rar
Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases, 7 edition.rar
Category:1942 births Category:Living people Category:American surgeons Category:University of California, San Francisco alumniChiral Discrimination of Ammonium, Tetra- and Pentacoordinate Thiocyanates by enantioselective Ion-Assisted Oxidative Cyclization of α-Allylthioketones. The reaction of (R)-α-allylthioketone with ammonium thiocyanates proceeds smoothly and readily affords the corresponding β-amino esters in high enantiomeric excess. The present study reports the development of the first enantioselective synthetic route to the β-amino esters via enantioselective ion-assisted oxidative cyclization, where an ammonium ion is used as a chiral metal-ligand complex. The reaction of (R)-α-allylthioketone with [Ru(p-cymene)Cl(2)]OTf (OTf=trifluoromethanesulfonate) and other metal salts generates the corresponding [Ru(cymene)(O(2)SCN)(2)](+) cation, where OTf becomes a chiral ligand to bind to the enantioselective metal ion. The aza-Claisen rearrangement then provides the desired β-amino esters in high enantiomeric excess with excellent diastereoselectivity. The synthetic utility of this strategy is demonstrated in the synthesis of the β-amino acid esters.TRANSFER NEWS: Twente keeper may want to quit Spain Twente keeper Filip Helander could be keen to join Liverpool It has long been mooted that his compatriot, Liverpool goalkeeper Iker Casillas, would be a perfect fit at Anfield. But according to the Dutch paper De Telegraaf, Helander could be next in line for a shock move across the channel. And the youngster - who joined Barcelona in 2007 after being the Dutch under-17 team's No.1 - could be interested in a move to Liverpool. Helander is being heavily linked with a switch to England after starting both legs of Twente's UEFA Cup game against Toulouse on Wednesday. The 21-year-old said: "I won't talk about that (whether I'll quit Spain), but I will say that I am 100 per cent focused on Twente."
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